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| Cat.No | ACP18358 | Target Name | RFTN1 |
|---|---|---|---|
| Target Synonyms | RFTN1; KIAA0084; MIG2; Raftlin; Cell migration-inducing gene 2 protein; Raft-linking protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-578 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q14699 |
|---|
Uniprot Id
Q14699
Target Species
Human
Target Name
RFTN1
Target Full Name
Raftlin
Target Function
Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. May regulate B-cell antigen receptor-mediated signaling. May play a pivotal role in the formation and/or maintenance of lipid rafts.
Target Subcellular Location
Cell membrane; Lipid-anchor. Cytoplasm. Membrane raft. Endosome. Early endosome.
Target Protein Families
Raftlin family
Target Tissue Specificity
Expressed in B-cells (at protein level). Expressed in dendritic cells and macrophages.
Target Synonyms
RFTN1; KIAA0084; MIG2; Raftlin; Cell migration-inducing gene 2 protein; Raft-linking protein
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