Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The Recombinant Human RAB11A protein, also known as Ras-related protein Rab-11A (Rab-11; YL8), is an essential component for advancing research in the field of cancer. RAB11A is a small GTPase involved in vesicular trafficking, membrane recycling, and regulation of endosomal membrane dynamics, which are critical processes in cellular homeostasis and tumorigenesis. Our Recombinant Human RAB11A protein is expressed in E.coli, ensuring the full length of the mature protein (2-213aa) is obtained. The N-terminal 6xHis-SUMO-tag allows for efficient purification while maintaining the protein's native structure and function. With a purity greater than 90% as determined by SDS-PAGE, our RAB11A protein guarantees consistent and reliable results in your research applications. Available in both liquid and lyophilized powder forms, our Recombinant Human RAB11A protein is ready to support your scientific endeavors.
The Recombinant Human RAB11A protein, also known as Ras-related protein Rab-11A (Rab-11; YL8), is an essential component for advancing research in the field of cancer. RAB11A is a small GTPase involved in vesicular trafficking, membrane recycling, and regulation of endosomal membrane dynamics, which are critical processes in cellular homeostasis and tumorigenesis.
Our Recombinant Human RAB11A protein is expressed in E.coli, ensuring the full length of the mature protein (2-213aa) is obtained. The N-terminal 6xHis-SUMO-tag allows for efficient purification while maintaining the protein’s native structure and function. With a purity greater than 90% as determined by SDS-PAGE, our RAB11A protein guarantees consistent and reliable results in your research applications. Available in both liquid and lyophilized powder forms, our Recombinant Human RAB11A protein is ready to support your scientific endeavors.
| Cat.No | ACP02569 | Target Name | RAB11A |
|---|---|---|---|
| Target Synonyms | member oncogene family; Rab-11; RAB11 A; RAB11; Rab11a; RAB11A member RAS oncogene family; Ras related protein Rab 11A; Ras related protein Rab11A; Ras-related protein Rab-11A; RB11A_HUMAN; YL 8; YL8, MGC1490; Rab 11; Rab 11A; RAB 11A | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 2-213aa |
| Mol Weight | 39.9kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P62491 |
|---|
Uniprot Id
P62491
Target Species
Human
Target Name
RAB11A
Target Full Name
Ras-related protein Rab-11A
Target Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.
Target Subcellular Location
Cell membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle membrane.
Target Protein Families
Small GTPase superfamily, Rab family
Target Research Area
Cancer
Target Synonyms
MGC1490; Rab 11; Rab 11A; RAB 11A, member oncogene family; Rab-11; RAB11 A; RAB11; Rab11a; RAB11A member RAS oncogene family; Ras related protein Rab 11A; Ras related protein Rab11A; Ras-related protein Rab-11A; RB11A_HUMAN; YL 8; YL8
Target Background
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
