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Recombinant Human Ras-related protein Rab-7b (RAB7B)

ACP12946

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Specifications

Cat.No	ACP12946	Target Name	RAB7B
Target Synonyms	MGC16212; MGC9726; RAB7; rab7B; RAB7B; member RAS oncogene family ; RAB7B_HUMAN; Ras related protein Rab 7b; Ras-related protein Rab-7B	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-199
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q96AH8

Background Information

Uniprot Id

Q96AH8
Target Species

Human
Target Name

RAB7B
Target Full Name

Ras-related protein Rab-7b
Target Function

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
Target Subcellular Location

Late endosome. Lysosome. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
Target Protein Families

Small GTPase superfamily, Rab family
Target Tissue Specificity

Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
Target Synonyms

MGC16212; MGC9726; RAB7; rab7B; RAB7B; member RAS oncogene family ; RAB7B_HUMAN; Ras related protein Rab 7b; Ras-related protein Rab-7B

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Recombinant Human Ras-related protein Rab-7b (RAB7B)

Specifications

Immunogen Information

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