Recombinant Human Ras-related protein Rap-2a (RAP2A)

Uniprot Id

P10114

Target Species

Human

Target Name

RAP2A

Target Full Name

Ras-related protein Rap-2a

Target Function

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.

Target Subcellular Location

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody.

Target Protein Families

Small GTPase superfamily, Ras family

Target Synonyms

RAP2A; Ras-related protein Rap-2a; RbBP-30

Target Background

Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including actin cytoskeleton reorganization; microvillus assembly; and positive regulation of protein autophosphorylation. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane.