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Amino acids 1-305 constitute the expression domain of recombinant Human RALGPS1. The calculated molecular weight for this RALGPS1 protein is 50.7 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 6xHis-SUMO tag into the RALGPS1 encoding gene fragment was conducted, allowing for easier detection and purification of the RALGPS1 protein in subsequent stages.Human ras-specific guanine nucleotide-releasing factor RALGPS1 is a key regulator of the Ras small GTPases. RALGPS1 activates RalA and RalB, influencing cellular processes like vesicle trafficking, cell migration, and oncogenic transformation. In cancer research, RALGPS1 is implicated in tumor progression and metastasis, making it a potential therapeutic target. In cell biology, RALGPS1 is essential for understanding Ras signaling and intracellular dynamics. Additionally, RALGPS1 plays a role in synaptic transmission and neurodevelopment. Investigating RALGPS1 provides insights into molecular mechanisms of Ras activation, offering potential applications in cancer therapeutics, neurological research, and broader cell signaling studies, enhancing the understanding of cellular processes and diseases.
Amino acids 1-305 constitute the expression domain of recombinant Human RALGPS1. The calculated molecular weight for this RALGPS1 protein is 50.7 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 6xHis-SUMO tag into the RALGPS1 encoding gene fragment was conducted, allowing for easier detection and purification of the RALGPS1 protein in subsequent stages.Human ras-specific guanine nucleotide-releasing factor RALGPS1 is a key regulator of the Ras small GTPases. RALGPS1 activates RalA and RalB, influencing cellular processes like vesicle trafficking, cell migration, and oncogenic transformation. In cancer research, RALGPS1 is implicated in tumor progression and metastasis, making it a potential therapeutic target. In cell biology, RALGPS1 is essential for understanding Ras signaling and intracellular dynamics. Additionally, RALGPS1 plays a role in synaptic transmission and neurodevelopment. Investigating RALGPS1 provides insights into molecular mechanisms of Ras activation, offering potential applications in cancer therapeutics, neurological research, and broader cell signaling studies, enhancing the understanding of cellular processes and diseases.
| Cat.No | ACP04019 | Target Name | RALGPS1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-305aa | Mol Weight | 50.7kDa |
| Protein Length | Full Length of Isoform 4 | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5JS13 |
|---|
Uniprot Id
Q5JS13
Target Species
Human
Target Name
RALGPS1
Target Full Name
Ras-specific guanine nucleotide-releasing factor RalGPS1
Target Function
Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization. Guanine nucleotide exchange factor for.
Target Subcellular Location
Cytoplasm. Cell membrane. Note=Associates with membranes through the PH domain.
Target Tissue Specificity
Widely expressed (at protein level). Isoform 2 is expressed in brain, colon, kidney, pancreas, prostate, skeletal muscle, small intestine, testis, thymus and uterus. Isoform 1 is expressed at high levels in heart and testis and at lower levels in brain, p
Target Research Area
Signal Transduction
Target Synonyms
RALGPS1; KIAA0351; RALGEF2; Ras-specific guanine nucleotide-releasing factor RalGPS1; Ral GEF with PH domain and SH3-binding motif 1; Ral guanine nucleotide exchange factor 2; RalGEF 2; RalA exchange factor RalGPS1
Target Background
Enables guanyl-nucleotide exchange factor activity. Involved in regulation of Ral protein signal transduction. Predicted to be located in cytoplasm and plasma membrane.
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