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Recombinant Human RelA-associated inhibitor (PPP1R13L), Truncated

ACP13000

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Specifications

Cat.No	ACP13000	Target Name	PPP1R13L
Target Synonyms	PPP1R13L; IASPP; NKIP1; PPP1R13BL; RAI; RelA-associated inhibitor; Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8WUF5

Background Information

Uniprot Id

Q8WUF5
Target Species

Human
Target Name

PPP1R13L
Target Full Name

RelA-associated inhibitor
Target Function

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

ASPP family
Target Tissue Specificity

Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.
Target Synonyms

PPP1R13L; IASPP; NKIP1; PPP1R13BL; RAI; RelA-associated inhibitor; Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein
Target Background

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.

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Recombinant Human RelA-associated inhibitor (PPP1R13L), Truncated

Specifications

Immunogen Information

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