Recombinant Human Renalase (RNLS)

Cat.No	ACP16802	Target Name	RNLS
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	18-342	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP16802

Target Name

RNLS

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

18-342

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q5VYX0

Background Information

Uniprot Id

Q5VYX0
Target Species

Human
Target Name

RNLS
Target Full Name

Renalase
Target Function

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Target Subcellular Location

Secreted.
Target Protein Families

Renalase family
Target Tissue Specificity

Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy
Target Synonyms

6530404N21Rik; AI452315; AW060440; C10orf59; Chromosome 10 open reading frame 59; FLJ11218; HGNC:25641; Hypothetical protein LOC55328; MAO C; MAO-C; mMAO C; Monoamine oxidase C; Monoamine oxidase-C; Renalase; Renalase FAD dependent amine oxidase ; RNLS; RNLS_HUMAN
Target Background

Enables several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in negative regulation of blood pressure and negative regulation of heart rate. Located in extracellular region. Implicated in essential hypertension and hypertension. Biomarker of end stage renal disease.

Recombinant Human Renalase (RNLS)

Specifications

Immunogen Information

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