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This high-quality Recombinant Human RPA2 protein is an essential component for research in epigenetics and nuclear signaling. RPA2, also known as Replication protein A 32 kDa subunit (RP-A p32), is a vital subunit of the heterotrimeric Replication protein A complex, which plays a key role in DNA replication, repair, and recombination processes. Our Recombinant Human RPA2 protein is expressed in E.coli, ensuring a partial protein length (1-267aa) that retains functionality. The N-terminal GST-tag facilitates efficient purification, while maintaining the protein's integrity and activity. With a purity greater than 90% as determined by SDS-PAGE, our RPA2 protein guarantees reliable and reproducible results in your research projects. Available in both liquid and lyophilized powder forms, our Recombinant Human RPA2 protein is poised to support your scientific discoveries.
This high-quality Recombinant Human RPA2 protein is an essential component for research in epigenetics and nuclear signaling. RPA2, also known as Replication protein A 32 kDa subunit (RP-A p32), is a vital subunit of the heterotrimeric Replication protein A complex, which plays a key role in DNA replication, repair, and recombination processes.
Our Recombinant Human RPA2 protein is expressed in E.coli, ensuring a partial protein length (1-267aa) that retains functionality. The N-terminal GST-tag facilitates efficient purification, while maintaining the protein’s integrity and activity. With a purity greater than 90% as determined by SDS-PAGE, our RPA2 protein guarantees reliable and reproducible results in your research projects. Available in both liquid and lyophilized powder forms, our Recombinant Human RPA2 protein is poised to support your scientific discoveries.
| Cat.No | ACP04657 | Target Name | RPA2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-267aa | Mol Weight | 55.9kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P15927 |
|---|
Uniprot Id
P15927
Target Species
Human
Target Name
RPA2
Target Full Name
Replication protein A 32 kDa subunit
Target Function
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Target Subcellular Location
Nucleus. Nucleus, PML body.
Target Protein Families
Replication factor A protein 2 family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
60S acidic ribosomal protein P1; AA409079; AI325195; AU020965; ik:tdsubc_2g1; M(2)21C; MGC137236; OTTHUMP00000004008 ; p32; p34; RCJMB04_6d17 replication protein A2; 32kDa ; REPA2; Replication factor A protein 2; Replication protein A 32 kDa subunit; Replication protein A 32kDa subunit; Replication protein A 34 kDa subunit; Replication protein A; Replication Protein A2 (32kDa); Replication protein A2; Replication protein A2; 32kDa ; RF-A protein 2; Rf-A2; RFA; RFA2_HUMAN; RP-A p32; RP-A p34; RP21C; RPA 2; RPA 32; RPA; Rpa2; RPA32 ; RPA34; RpLP1; RpP2; xx:tdsubc_2g1; zgc:109822
Target Background
Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions._x000D_ Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
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