Recombinant Human REST corepressor 1 (RCOR1),Truncated

Uniprot Id

Q9UKL0

Target Species

Human

Target Name

RCOR1

Target Full Name

REST corepressor 1

Target Function

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Target Subcellular Location

Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.

Target Protein Families

CoREST family

Target Tissue Specificity

Ubiquitously expressed.

Target Research Area

Cancer

Target Synonyms

COREST; KIAA0071; Nr2b2; Nuclear receptor coregulator 1; Nuclear receptor subfamily 2 group B member 2; Protein CoREST; RCOR; Rcor1; RCOR1_HUMAN; REST corepressor 1; Retinoic acid receptor RXR-beta; Retinoid X receptor beta; Rxrb

Target Background

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).