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| Cat.No | ACP01967 | Target Name | ARHGEF12 |
|---|---|---|---|
| Target Synonyms | Leukemia-associated RhoGEF | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 367-558aa |
| Mol Weight | 28.7 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NZN5 |
|---|
Uniprot Id
Q9NZN5
Target Species
Human
Target Name
ARHGEF12
Target Full Name
Rho guanine nucleotide exchange factor 12
Target Function
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Target Involvement
A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with KMT2A/MLL1.
Target Subcellular Location
Cytoplasm. Membrane.
Target Tissue Specificity
Ubiquitously expressed. Isoform 2 is found in jejunum and testis.
Target Research Area
Signal Transduction
Target Synonyms
ARHGC_HUMAN; ARHGEF12; KIAA0382; leukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; PRO2792; Rho guanine exchange factor (GEF) 12; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12; Similar to Mouse Lsc oncogene
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