Recombinant Human Rhodopsin kinase (GRK1)

Uniprot Id

Q15835

Target Species

Human

Target Name

GRK1

Target Full Name

Rhodopsin kinase GRK1

Target Function

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. May play a role in the maintenance of the outer nuclear layer in the retina.

Target Involvement

Night blindness, congenital stationary, Oguchi type 2 (CSNBO2)

Target Subcellular Location

Membrane; Lipid-anchor. Cell projection, cilium, photoreceptor outer segment.

Target Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily

Target Tissue Specificity

Retinal-specific. Expressed in rods and cones cells.

Target Synonyms

EC=2.7.11.14; G protein-coupled receptor kinase 1; GPRK1; Grk1; Rhodopsin kinase; RHOK; RK; RK_HUMAN

Target Background

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).