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Amino acids 2-322 constitute the expression domain of recombinant Human RBKS. This RBKS protein is theoretically predicted to have a molecular weight of 50 kDa. This RBKS protein is produced using e.coli expression system. The RBKS coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant RBKS protein in following stages of expression and purification.Ribokinase (RBKS) is a crucial enzyme involved in the phosphorylation of ribose, playing a central role in the cellular metabolism of carbohydrates. As part of the pentose phosphate pathway, RBKS catalyzes the conversion of ribose to ribose-5-phosphate by transferring a phosphate group from ATP to ribose. This phosphorylation step is vital for the subsequent utilization of ribose-5-phosphate in various metabolic pathways, including nucleotide biosynthesis and the generation of reducing equivalents. Beyond its central role in energy metabolism, RBKS has been implicated in cellular stress responses and is associated with the pathogenesis of certain diseases. Investigating RBKS provides insights into the intricate regulation of cellular processes and its potential implications in metabolic disorders.
Amino acids 2-322 constitute the expression domain of recombinant Human RBKS. This RBKS protein is theoretically predicted to have a molecular weight of 50 kDa. This RBKS protein is produced using e.coli expression system. The RBKS coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant RBKS protein in following stages of expression and purification.Ribokinase (RBKS) is a crucial enzyme involved in the phosphorylation of ribose, playing a central role in the cellular metabolism of carbohydrates. As part of the pentose phosphate pathway, RBKS catalyzes the conversion of ribose to ribose-5-phosphate by transferring a phosphate group from ATP to ribose. This phosphorylation step is vital for the subsequent utilization of ribose-5-phosphate in various metabolic pathways, including nucleotide biosynthesis and the generation of reducing equivalents. Beyond its central role in energy metabolism, RBKS has been implicated in cellular stress responses and is associated with the pathogenesis of certain diseases. Investigating RBKS provides insights into the intricate regulation of cellular processes and its potential implications in metabolic disorders.
| Cat.No | ACP03376 | Target Name | RBKS |
|---|---|---|---|
| Target Synonyms | RBKS; RBSK; Ribokinase; RK; EC 2.7.1.15 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 2-322aa |
| Mol Weight | 50.0kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H477 |
|---|
Uniprot Id
Q9H477
Target Species
Human
Target Name
RBKS
Target Full Name
Ribokinase
Target Function
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Carbohydrate kinase PfkB family, Ribokinase subfamily
Target Research Area
Metabolism
Target Synonyms
RBKS; RBSK; Ribokinase; RK; EC 2.7.1.15
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