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Discover the power of precision with our Recombinant Human RNASEH1 protein, an essential tool for advancing research in epigenetics and nuclear signaling. Ribonuclease H1 (RNase H1; Ribonuclease H type II) is a critical enzyme involved in the removal of RNA:DNA hybrids formed during replication, transcription, and repair processes. RNASEH1 plays a pivotal role in maintaining genome stability and has been implicated in various biological pathways, making it an important target for scientific inquiry. Our Recombinant Human RNASEH1 protein is expressed in E.coli, resulting in a full-length protein (1-286aa) that retains its native folding and function. The N-terminal 6xHis-tag allows for efficient purification, while the purity of the protein, greater than 85% as determined by SDS-PAGE, ensures consistent and reliable results for your research endeavors. Available in both liquid and lyophilized powder forms, our Recombinant Human RNASEH1 protein is the ideal choice for your epigenetic and nuclear signaling investigations.
Discover the power of precision with our Recombinant Human RNASEH1 protein, an essential tool for advancing research in epigenetics and nuclear signaling. Ribonuclease H1 (RNase H1; Ribonuclease H type II) is a critical enzyme involved in the removal of RNA:DNA hybrids formed during replication, transcription, and repair processes. RNASEH1 plays a pivotal role in maintaining genome stability and has been implicated in various biological pathways, making it an important target for scientific inquiry.
Our Recombinant Human RNASEH1 protein is expressed in E.coli, resulting in a full-length protein (1-286aa) that retains its native folding and function. The N-terminal 6xHis-tag allows for efficient purification, while the purity of the protein, greater than 85% as determined by SDS-PAGE, ensures consistent and reliable results for your research endeavors. Available in both liquid and lyophilized powder forms, our Recombinant Human RNASEH1 protein is the ideal choice for your epigenetic and nuclear signaling investigations.
| Cat.No | ACP02404 | Target Name | RNASEH1 |
|---|---|---|---|
| Target Synonyms | RNASEH1; RNH1; Ribonuclease H1; RNase H1; EC 3.1.26.4; Ribonuclease H type II | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-286aa |
| Mol Weight | 37.6 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60930 |
|---|
Uniprot Id
O60930
Target Species
Human
Target Name
RNASEH1
Target Full Name
Ribonuclease H1
Target Function
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II.
Target Involvement
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2 (PEOB2)
Target Subcellular Location
Cytoplasm.
Target Protein Families
RNase H family
Target Tissue Specificity
Ubiquitous.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
RNASEH1; RNH1; Ribonuclease H1; RNase H1; EC 3.1.26.4; Ribonuclease H type II
Target Background
This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17.
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