Recombinant Human Ribonuclease UK114 (HRSP12)

Cat.No	ACP22890	Target Name	RIDA
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-137	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP22890

Target Name

RIDA

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-137

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P52758

Background Information

Uniprot Id

P52758
Target Species

Human
Target Name

RIDA
Target Full Name

2-iminobutanoate/2-iminopropanoate deaminase
Target Function

Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.; Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.
Target Subcellular Location

Cytoplasm. Nucleus. Peroxisome. Mitochondrion.
Target Protein Families

RutC family
Target Tissue Specificity

Expressed predominantly in liver and kidney. Lower levels in lung and brain.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

14.5 kDa translational inhibitor protein; 2-iminobutanoate/2-iminopropanoate deaminase; Heat responsive protein 12; Heat-responsive protein 12; Hrsp12; p14.5; Perchloric acid soluble protein; PSP; Reactive intermediate imine deaminase A homolog; Ribonuclease UK114; RIDA; Translational inhibitor p14.5; Translational inhibitor protein p14.5; UK114; UK114 antigen homolog; UK114_HUMAN
Target Background

Enables 2-iminobutanoate deaminase activity and mRNA binding activity. Involved in mRNA catabolic process; mRNA destabilization; and organonitrogen compound catabolic process. Located in cytoplasm and nucleus.

Recombinant Human Ribonuclease UK114 (HRSP12)

Specifications

Immunogen Information

Inquire Recombinant Human Ribonuclease UK114 (HRSP12) Now

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