Recombinant Human Ribosome biogenesis protein WDR12 (WDR12)

Uniprot Id

Q9GZL7

Target Species

Human

Target Name

WDR12

Target Full Name

Ribosome biogenesis protein WDR12

Target Function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Target Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm.

Target Protein Families

WD repeat WDR12/YTM1 family

Target Synonyms

FLJ10881; FLJ12719; FLJ12720; OTTHUMP00000163754; Ribosome biogenesis protein WDR12; WD repeat containing protein 12; WD repeat domain 12; WD repeat-containing protein 12; WDR 12; Wdr12; WDR12_HUMAN; YTM1

Target Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.