Recombinant Human RING finger and CCCH-type zinc finger domain-containing protein 2 (RC3H2), Truncated

Cat.No	ACP10619	Target Name	RC3H2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10619

Target Name

RC3H2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9HBD1

Background Information

Uniprot Id

Q9HBD1
Target Species

Human
Target Name

RC3H2
Target Full Name

Roquin-2
Target Function

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation. miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression. Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains. Involved in the ubiquitination of MAP3K5. Able to interact with double-stranded RNA (dsRNA).
Target Subcellular Location

Cytoplasm, P-body.
Target Tissue Specificity

Expressed in spleen, testis, ovary and small intestine.
Target Synonyms

2900024N03Rik; 9430019J22Rik; D930043C02Rik; FLJ20301; FLJ20713; Membrane associated DNA binding protein; Membrane associated nucleic acid binding protein; Membrane-associated nucleic acid-binding protein; MGC52176; MNAB; OTTHUMP00000022076; OTTHUMP00000022077; OTTMUSP00000013545; OTTMUSP00000013546; Rc3h2; RC3H2_HUMAN; Ring finger and CCCH type domains 2; RING finger and CCCH type zinc finger domain containing protein 2; Ring finger and CCCH-type zinc finger domain-containing protein 2; ring finger and CCCH-type zinc finger domains 2; RING finger protein 164; RNF164; roquin-2; RP23-321B3.1

Recombinant Human RING finger and CCCH-type zinc finger domain-containing protein 2 (RC3H2), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human RING finger and CCCH-type zinc finger domain-containing protein 2 (RC3H2), Truncated Now

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