Recombinant Human RING finger protein 112 (RNF112), Truncated

Uniprot Id

Q9ULX5

Target Species

Human

Target Name

RNF112

Target Full Name

RING finger protein 112

Target Function

E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density.

Target Subcellular Location

Membrane; Multi-pass membrane protein. Membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Nucleus, nuclear body. Nucleus, nucleoplasm. Endosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse, postsynaptic density. Perikaryon. Cell projection, neuron projection.

Target Protein Families

TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily

Target Tissue Specificity

Predominantly expressed in brain. Decreased expression in glioma brain tumors as compared to normal brains (at protein level).

Target Synonyms

RNF112; BFP; ZNF179; RING finger protein 112; Brain finger protein; Zinc finger protein 179

Target Background

This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17.