Recombinant Human RING finger protein 126 (RNF126)

Uniprot Id

Q9BV68

Target Species

Human

Target Name

RNF126

Target Full Name

E3 ubiquitin-protein ligase RNF126

Target Function

E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Tissue Specificity

Highly expressed in liver and testis.

Target Research Area

Cell Biology

Target Synonyms

E3 ubiquitin-protein ligase RNF126; FLJ20552; MGC1022; MGC14317; RING finger protein 126; RN126_HUMAN; RNF 126; RNF126

Target Background

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.