Recombinant Human RNA-binding motif, single-stranded-interacting protein 1 (RBMS1)

Uniprot Id

P29558

Target Species

Human

Target Name

RBMS1

Target Full Name

RNA-binding motif, single-stranded-interacting protein 1

Target Function

Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Highest amounts are found in placenta, lung and heart.

Target Synonyms

c myc gene single strand binding protein 2; C2orf12; Cervical cancer oncogene 4; HCC 4; MSSP 2; MSSP 3; MSSP; MSSP-1; MSSP-2; MSSP-3; MSSP1; RBMS1; RBMS1_HUMAN; RNA binding motif; single stranded interacting protein 1; RNA-binding motif; SCR2; Single stranded DNA binding protein MSSP 1; Single-stranded DNA-binding protein MSSP-1; single-stranded-interacting protein 1; suppressor of cdc 2 (cdc13) with RNA binding motif 2; Suppressor of CDC2 with RNA binding motif 2; Suppressor of CDC2 with RNA-binding motif 2; YC1

Target Background

This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12.