Recombinant Human RNA polymerase II elongation factor ELL (ELL)

Uniprot Id

P55199

Target Species

Human

Target Name

ELL

Target Full Name

RNA polymerase II elongation factor ELL

Target Function

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.

Target Involvement

A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with KMT2A/MLL1. The result is a rogue activator protein.

Target Subcellular Location

Nucleus. Nucleus speckle. Nucleus, Cajal body.

Target Protein Families

ELL/occludin family

Target Tissue Specificity

Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.

Target Synonyms

ELL; C19orf17RNA polymerase II elongation factor ELL; Eleven-nineteen lysine-rich leukemia protein

Target Background

Enables phosphatase binding activity. Involved in positive regulation of transcription, DNA-templated and snRNA transcription. Located in cytosol; nuclear body; and transcriptionally active chromatin. Part of transcription elongation factor complex.