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Recombinant Human RNA pseudouridylate synthase domain-containing protein 4 (RPUSD4)

ACP14419

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP14419 Target NameRPUSD4
Target SynonymsRNA pseudouridylate synthase domain-containing protein 4; rpusd4; RUSD4_HUMANFormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Expression Range1-377
Protein LengthFull length proteinPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ96CM3
Background Information
  • Uniprot Id

    Q96CM3

  • Target Species

    Human

  • Target Name

    RPUSD4

  • Target Full Name

    Pseudouridylate synthase RPUSD4, mitochondrial

  • Target Function

    Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation.

  • Target Subcellular Location

    Mitochondrion matrix.

  • Target Protein Families

    Pseudouridine synthase RluA family

  • Target Synonyms

    RNA pseudouridylate synthase domain-containing protein 4; rpusd4; RUSD4_HUMAN

  • Target Background

    Enables mitochondrial ribosomal large subunit rRNA binding activity; pseudouridine synthase activity; and tRNA binding activity. Involved in mitochondrial tRNA pseudouridine synthesis and positive regulation of mitochondrial translation. Located in mitochondrion; nucleoplasm; and ribonucleoprotein granule.

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