Recombinant Human S-arrestin (SAG)

Unlock the potential of signal transduction research with our Recombinant Human SAG protein. S-arrestin, also known as retinal S-antigen or rod photoreceptor arrestin, plays a crucial role in the regulation of phototransduction in the retina. By modulating the activity of rhodopsin, a light-sensitive G protein-coupled receptor, SAG contributes to the desensitization and adaptation of photoreceptor cells, allowing them to adjust to changing light conditions. Our Recombinant Human SAG protein is expressed in yeast, resulting in a full-length protein (1-405aa) that maintains its native structure and function. The N-terminal 6xHis-tag allows for efficient purification and easy detection of the protein. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human SAG protein ensures reliable and consistent results for your signal transduction research. Available in both liquid and lyophilized powder forms, our Recombinant Human SAG protein is an indispensable tool for exploring the complex world of cellular signaling pathways.

ACP02587

Unlock the potential of signal transduction research with our Recombinant Human SAG protein. S-arrestin, also known as retinal S-antigen or rod photoreceptor arrestin, plays a crucial role in the regulation of phototransduction in the retina. By modulating the activity of rhodopsin, a light-sensitive G protein-coupled receptor, SAG contributes to the desensitization and adaptation of photoreceptor cells, allowing them to adjust to changing light conditions.
Our Recombinant Human SAG protein is expressed in yeast, resulting in a full-length protein (1-405aa) that maintains its native structure and function. The N-terminal 6xHis-tag allows for efficient purification and easy detection of the protein. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human SAG protein ensures reliable and consistent results for your signal transduction research. Available in both liquid and lyophilized powder forms, our Recombinant Human SAG protein is an indispensable tool for exploring the complex world of cellular signaling pathways.

Number

Cat.No	ACP02587	Target Name	SAG
Form	Liquid or Lyophilized powder	Expression System	Yeast
Expression Range	1-405aa	Mol Weight	47.1kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02587

Target Name

SAG

Form

Liquid or Lyophilized powder

Expression System

Yeast

Expression Range

1-405aa

Mol Weight

47.1kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P10523

Background Information

Uniprot Id

P10523
Target Species

Human
Target Name

SAG
Target Full Name

S-arrestin
Target Function

Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
Target Involvement

Night blindness, congenital stationary, Oguchi type 1 (CSNBO1); Retinitis pigmentosa 47 (RP47)
Target Subcellular Location

Cell projection, cilium, photoreceptor outer segment. Membrane; Peripheral membrane protein.
Target Protein Families

Arrestin family
Target Tissue Specificity

Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level).
Target Research Area

Neuroscience, Signal Transduction
Target Synonyms

48 kDa protein; Arrestin 1; Arrestin; ARRS_HUMAN; Retinal S antigen (48 KDa protein); Retinal S-antigen; Rod photoreceptor arrestin; RP47; S antigen; S antigen retina and pineal gland (arrestin); S arrestin; S-AG; S-arrestin; SAG
Target Background

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.

Recombinant Human S-arrestin (SAG)

Specifications

Immunogen Information

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