Recombinant Human Secreted frizzled-related protein 5 (SFRP5)

Uniprot Id

Q5T4F7

Target Species

Human

Target Name

SFRP5

Target Full Name

Secreted frizzled-related protein 5

Target Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Target Subcellular Location

Secreted.

Target Protein Families

Secreted frizzled-related protein (sFRP) family

Target Tissue Specificity

Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.

Target Synonyms

SFRP5; FRP1B; SARP3; Secreted frizzled-related protein 5; sFRP-5; Frizzled-related protein 1b; FRP-1b; Secreted apoptosis-related protein 3; SARP-3

Target Background

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.