Recombinant Human Secretoglobin family 3A member 2 (SCGB3A2)

Uniprot Id

Q96PL1

Target Species

Human

Target Name

SCGB3A2

Target Full Name

Secretoglobin family 3A member 2

Target Function

Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH)

Target Subcellular Location

Secreted.

Target Protein Families

Secretoglobin family, UGRP subfamily

Target Tissue Specificity

Highly expressed in lung and trachea. Detected throughout the airway epithelium in lung, with slightly higher expression in large airways. Found in lung submucosal gland acinus where it localizes to serous-like cells. Probably expressed in club/Clara cell

Target Synonyms

LU103; Pneumo secretory protein 1; PnSP-1; PNSP1; SCGB3A2; Secretoglobin family 3A member 2; SG3A2_HUMAN; UGRP1; Uteroglobin-related protein 1

Target Background

The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.