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Dive into cardiovascular research with our high-quality Recombinant Human PLA2R1 protein. The secretory phospholipase A2 receptor (PLA2R1) is a type I transmembrane glycoprotein, which plays a crucial role in modulating the actions of secretory phospholipase A2 (sPLA2) enzymes, involved in lipid metabolism and inflammatory responses. This makes PLA2R1 an important target in understanding the complex mechanisms underlying cardiovascular health and disease. Our Recombinant Human PLA2R1 protein is expressed in yeast, ensuring optimal protein folding and glycosylation. The partial protein (395-530aa) retains its native structure and functionality, while the N-terminal 6xHis-tag allows for efficient purification and detection. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human PLA2R1 protein delivers reliable results for your cardiovascular research projects. The protein is available in both liquid and lyophilized powder forms, providing you with flexibility and convenience in your experiments.
Dive into cardiovascular research with our high-quality Recombinant Human PLA2R1 protein. The secretory phospholipase A2 receptor (PLA2R1) is a type I transmembrane glycoprotein, which plays a crucial role in modulating the actions of secretory phospholipase A2 (sPLA2) enzymes, involved in lipid metabolism and inflammatory responses. This makes PLA2R1 an important target in understanding the complex mechanisms underlying cardiovascular health and disease.
Our Recombinant Human PLA2R1 protein is expressed in yeast, ensuring optimal protein folding and glycosylation. The partial protein (395-530aa) retains its native structure and functionality, while the N-terminal 6xHis-tag allows for efficient purification and detection. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human PLA2R1 protein delivers reliable results for your cardiovascular research projects. The protein is available in both liquid and lyophilized powder forms, providing you with flexibility and convenience in your experiments.
| Cat.No | ACP03852 | Target Name | PLA2R1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 395-530aa | Mol Weight | 17.4kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13018 |
|---|
Uniprot Id
Q13018
Target Species
Human
Target Name
PLA2R1
Target Full Name
Secretory phospholipase A2 receptor
Target Function
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.; [Soluble secretory phospholipase A2 receptor]: Secreted.; [Isoform 2]: Secreted.
Target Tissue Specificity
Expressed in podocytes (at protein level). Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level.
Target Research Area
Cardiovascular
Target Synonyms
180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; CLEC13C ; M type receptor ; M-type receptor; Phospholipase A2 receptor 1 ; PLA2 R ; PLA2-R; PLA2G1R ; PLA2IR ; PLA2R; PLA2R_HUMAN; PLA2R1; Soluble PLA2-R; Soluble PLA2R; Soluble secretory phospholipase A2 receptor
Target Background
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.
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