Recombinant Human Septin-12 (SEPT12)

Uniprot Id

Q8IYM1

Target Species

Human

Target Name

SEPT12

Target Full Name

Septin-12

Target Function

Filament-forming cytoskeletal GTPase. Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. May play a role in cytokinesis (Potential).

Target Involvement

Spermatogenic failure 10 (SPGF10)

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Nucleus. Cell projection, cilium, flagellum.

Target Protein Families

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family

Target Tissue Specificity

Widely expressed. Expressed in lymph node.

Target Research Area

Cell Biology

Target Synonyms

SEP12_HUMAN; SEPT12; Septin-12; Septin12

Target Background

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.