Recombinant Human Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB)

Uniprot Id

P83111

Target Species

Human

Target Name

LACTB

Target Full Name

Serine beta-lactamase-like protein LACTB, mitochondrial

Target Function

Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism.

Target Subcellular Location

Mitochondrion.

Target Protein Families

Peptidase S12 family

Target Tissue Specificity

Expressed predominantly in skeletal muscle.

Target Synonyms

LACTB; MRPL56; UNQ843/PRO1781Serine beta-lactamase-like protein LACTB; mitochondrial; EC 3.4.-.-

Target Background

This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms.