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This Recombinant Human STK11 protein is an essential tool for your apoptosis research needs. Serine/threonine-protein kinase STK11, also known as LKB1 or PJS, is a key regulator of cell polarity and energy metabolism. Its involvement in apoptosis and other cellular processes, such as cell proliferation and differentiation, makes it a vital target for understanding the intricate mechanisms governing cell fate. Our Recombinant Human STK11 protein is expressed in E.coli, ensuring robust production of the full length of mature protein (1-430aa). The N-terminal 6xHis-SUMO tag allows for efficient purification and detection while maintaining the protein's native structure and function. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human STK11 protein ensures reliability and reproducibility in your experiments. Available in both liquid and lyophilized powder forms, our product offers the versatility to suit your specific research requirements.
This Recombinant Human STK11 protein is an essential tool for your apoptosis research needs. Serine/threonine-protein kinase STK11, also known as LKB1 or PJS, is a key regulator of cell polarity and energy metabolism. Its involvement in apoptosis and other cellular processes, such as cell proliferation and differentiation, makes it a vital target for understanding the intricate mechanisms governing cell fate.
Our Recombinant Human STK11 protein is expressed in E.coli, ensuring robust production of the full length of mature protein (1-430aa). The N-terminal 6xHis-SUMO tag allows for efficient purification and detection while maintaining the protein’s native structure and function. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human STK11 protein ensures reliability and reproducibility in your experiments. Available in both liquid and lyophilized powder forms, our product offers the versatility to suit your specific research requirements.
| Cat.No | ACP04091 | Target Name | STK11 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-430aa | Mol Weight | 64.3kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q15831 |
|---|
Uniprot Id
Q15831
Target Species
Human
Target Name
STK11
Target Full Name
Serine/threonine-protein kinase STK11
Target Function
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair.; Has a role in spermiogenesis.
Target Involvement
Peutz-Jeghers syndrome (PJS); Testicular germ cell tumor (TGCT)
Target Subcellular Location
Nucleus. Cytoplasm. Membrane. Mitochondrion.; [Isoform 2]: Nucleus. Cytoplasm. Note=Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
Target Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, LKB1 subfamily
Target Tissue Specificity
Ubiquitously expressed. Strongest expression in testis and fetal liver.
Target Research Area
Apoptosis
Target Synonyms
hLKB1; Liver kinase B1; LKB1; PJS; Polarization related protein LKB1; Renal carcinoma antigen NY-REN-19; Serine/Threonine Kinase 11; Serine/threonine protein kinase 11; Serine/threonine protein kinase LKB1; Serine/threonine protein kinase STK11; Serine/threonine-protein kinase 11; Serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase XEEK1; Stk11; STK11_HUMAN
Target Background
The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
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