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Recombinant Human SET domain-containing protein 5 (SETD5), Truncated

ACP11578

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Specifications

Cat.No	ACP11578	Target Name	SETD5
Target Synonyms	SET domain containing 5; SET domain-containing protein 5; Setd5; SETD5_HUMAN	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9C0A6

Background Information

Uniprot Id

Q9C0A6
Target Species

Human
Target Name

SETD5
Target Full Name

Histone-lysine N-methyltransferase SETD5
Target Function

Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion.
Target Involvement

Mental retardation, autosomal dominant 23 (MRD23)
Target Subcellular Location

Nucleus. Chromosome.
Target Synonyms

SET domain containing 5; SET domain-containing protein 5; Setd5; SETD5_HUMAN
Target Background

This function of this gene has yet to be determined but based on sequence similarity to other SET domain proteins it may function as a histone methyltransferase. Mutations in this gene have been associated with an autosomal dominant form of intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Recombinant Human SET domain-containing protein 5 (SETD5), Truncated

Specifications

Immunogen Information

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