Recombinant Human Signal peptide peptidase-like 2A (SPPL2A), Truncated

Uniprot Id

Q8TCT8

Target Species

Human

Target Name

SPPL2A

Target Full Name

Signal peptide peptidase-like 2A

Target Function

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.

Target Subcellular Location

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.

Target Protein Families

Peptidase A22B family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

SPPL2A; IMP3; PSL2; PSEC0147; Signal peptide peptidase-like 2A; SPP-like 2A; SPPL2a; EC 3.4.23.-; Intramembrane protease 3; IMP-3; Presenilin-like protein 2

Target Background

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.