Recombinant Human SLP adapter and CSK-interacting membrane protein (SCIMP), Truncated

Uniprot Id

Q6UWF3

Target Species

Human

Target Name

SCIMP

Target Full Name

SLP adapter and CSK-interacting membrane protein

Target Function

Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells. It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans. It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases.

Target Subcellular Location

Cell membrane; Single-pass membrane protein. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Cell projection, ruffle. Cell projection, filopodium.

Target Tissue Specificity

Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells. Faintly expressed in the majority of

Target Research Area

Others

Target Synonyms

SCIMP; C17orf87; UNQ5783/PRO16090; SLP adapter and CSK-interacting membrane protein; SLP65/SLP76, Csk-interacting membrane protein