Recombinant Human Small conductance calcium-activated potassium channel protein 1 (KCNN1), Truncated

Uniprot Id

Q92952

Target Species

Human

Target Name

KCNN1

Target Full Name

Small conductance calcium-activated potassium channel protein 1

Target Function

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel KCNN family, KCa2.1/KCNN1 subfamily

Target Synonyms

KCNN1; SK; Small conductance calcium-activated potassium channel protein 1; SK1; SKCa 1; SKCa1; KCa2.1

Target Background

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.