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The recombinant Human SPRR2B was expressed with the amino acid range of 1-72. This SPRR2B protein is expected to have a theoretical molecular weight of 12 kDa. This protein is generated in a yeast-based system. The SPRR2B gene fragment has been modified by fusing the N-terminal 10xHis tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant SPRR2B protein during the following stages.The human small proline-rich protein 2B (SPRR2B) is characterized by its high proline content and is involved in various cellular processes, particularly in the context of epithelial development and barrier function. SPRR2B is expressed in epithelial tissues, contributing to the structural integrity of the epithelium. It is found in the skin, esophagus, and other stratified squamous epithelia. It also participates in the process of cornification, a terminal differentiation process in epithelial cells where cells undergo structural changes to form the outermost layers of the epidermis. SPRR2B is implicated in the maintenance of the epidermal barrier, protecting the underlying tissues from external environmental factors. Aberrant expression of SPRR2B has been observed in certain skin disorders, suggesting its potential role in dermatological conditions. Research on SPRR2B focuses on understanding its precise functions in epithelial biology, including its role in tissue development, barrier formation, and its implications for skin health and disease.
The recombinant Human SPRR2B was expressed with the amino acid range of 1-72. This SPRR2B protein is expected to have a theoretical molecular weight of 12 kDa. This protein is generated in a yeast-based system. The SPRR2B gene fragment has been modified by fusing the N-terminal 10xHis tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant SPRR2B protein during the following stages.The human small proline-rich protein 2B (SPRR2B) is characterized by its high proline content and is involved in various cellular processes, particularly in the context of epithelial development and barrier function. SPRR2B is expressed in epithelial tissues, contributing to the structural integrity of the epithelium. It is found in the skin, esophagus, and other stratified squamous epithelia. It also participates in the process of cornification, a terminal differentiation process in epithelial cells where cells undergo structural changes to form the outermost layers of the epidermis. SPRR2B is implicated in the maintenance of the epidermal barrier, protecting the underlying tissues from external environmental factors. Aberrant expression of SPRR2B has been observed in certain skin disorders, suggesting its potential role in dermatological conditions. Research on SPRR2B focuses on understanding its precise functions in epithelial biology, including its role in tissue development, barrier formation, and its implications for skin health and disease.
| Cat.No | ACP02249 | Target Name | Sprr2b |
|---|---|---|---|
| Target Synonyms | SPRR2B; Small proline-rich protein 2B; SPR-2B | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 1-72aa |
| Mol Weight | 12.0kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P35325 |
|---|
Uniprot Id
P35325
Target Species
Human
Target Name
SPRR2B
Target Full Name
Small proline-rich protein 2B
Target Function
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Cornifin (SPRR) family
Target Tissue Specificity
Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
Target Research Area
others
Target Synonyms
SPRR2B; Small proline-rich protein 2B; SPR-2B
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