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| Cat.No | ACP07458 | Target Name | SMO |
|---|---|---|---|
| Target Synonyms | SMO; SMOH; Smoothened homolog; SMO; Protein Gx | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q99835 |
|---|
Uniprot Id
Q99835
Target Species
Human
Target Name
SMO
Target Full Name
Protein smoothened
Target Function
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
Target Involvement
Curry-Jones syndrome (CRJS)
Target Subcellular Location
Membrane; Multi-pass membrane protein. Cell projection, cilium.
Target Protein Families
G-protein coupled receptor Fz/Smo family
Target Synonyms
SMO; SMOH; Smoothened homolog; SMO; Protein Gx
Target Background
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
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