Recombinant Human Sodium channel subunit beta-3 (SCN3B), Truncated

Uniprot Id

Q9NY72

Target Species

Human

Target Name

SCN3B

Target Full Name

Sodium channel regulatory subunit beta-3

Target Function

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

Target Involvement

Brugada syndrome 7 (BRGDA7); Atrial fibrillation, familial, 16 (ATFB16)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Sodium channel auxiliary subunit SCN3B (TC 8.A.17) family

Target Tissue Specificity

Expressed in the atrium.

Target Synonyms

1110001K16Rik; 4833414B02Rik; HSA243396; KIAA1158; MGC136997; MGC80155; Scn3b; SCN3B_HUMAN; SCNB3; Sodium channel subunit beta-3; Sodium channel, beta 3 subunit; sodium channel, voltage-gated, type III, beta

Target Background

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified.