Recombinant Human Sodium/potassium/calcium exchanger 1 (SLC24A1), Truncated

Uniprot Id

O60721

Target Species

Human

Target Name

SLC24A1

Target Full Name

Sodium/potassium/calcium exchanger 1

Target Function

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Target Involvement

Night blindness, congenital stationary, 1D (CSNB1D)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily

Target Tissue Specificity

Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.

Target Synonyms

CSNB1D; HsT17412; KIAA0702; Na(+)/K(+)/Ca(2+) exchange protein 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; NCKX; NCKX1; NCKX1_HUMAN; Retinal rod Na Ca+K exchanger; Retinal rod Na+/Ca+/K+ exchanger; Retinal rod Na-Ca+K exchanger; RODX; Slc24a1; Sodium/potassium/calcium exchanger 1; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1; Solute carrier family 24 member 1