Recombinant Human Solute carrier family 12 member 2 (SLC12A2), Truncated

Uniprot Id

P55011

Target Species

Human

Target Name

SLC12A2

Target Full Name

Solute carrier family 12 member 2

Target Function

Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.

Target Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein.

Target Protein Families

SLC12A transporter family

Target Tissue Specificity

Expressed in many tissues.

Target Synonyms

Basolateral Na-K-Cl symporter; BSC; BSC2; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; mBSC2; MGC104233; NKCC1; PPP1R141; Protein phosphatase 1; regulatory subunit 141; S12A2_HUMAN; Slc12a2; sodium-potassium-chloride cotransporter 1; Solute carrier family 12 (sodium/potassium/chloride transporter); member 2; solute carrier family 12 (sodium/potassium/chloride transporters) member 2; Solute carrier family 12 member 2; sy-ns

Target Background

The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.