Recombinant Human Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4), Truncated

Uniprot Id

P14672

Target Species

Human

Target Name

SLC2A4

Target Full Name

Solute carrier family 2, facilitated glucose transporter member 4

Target Function

Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.

Target Involvement

Diabetes mellitus, non-insulin-dependent (NIDDM)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.

Target Protein Families

Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily

Target Tissue Specificity

Skeletal and cardiac muscles; brown and white fat.

Target Synonyms

insulin-responsive; Glucose transporter GLUT 4; Glucose transporter type 4; Glucose transporter type 4 insulin responsive; GLUT 4; GLUT-4; GLUT4; GTR4_HUMAN; Insulin responsive glucose transporter type 4; kug; SLC 2A4; SLC2A4; solute carrier family 2 (facilitated glucose transporter) member 4; Solute carrier family 2 member 4; Solute carrier family 2, facilitated glucose transporter member 4

Target Background

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).