Recombinant Human Solute carrier family 22 member 7 (SLC22A7), Truncated

Uniprot Id

Q9Y694

Target Species

Human

Target Name

SLC22A7

Target Full Name

Solute carrier family 22 member 7

Target Function

Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.

Target Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein. Note=Apical side of the renal tubule.

Target Protein Families

Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family

Target Tissue Specificity

Expressed in liver and kidney.

Target Synonyms

hOAT2; liver specific transporter; NLT; Novel liver transporter; OAT2; Organic anion transporter 2; Organic anion transporter member 7; Organic anion transporter member 7 Fragment; S22A7_HUMAN; SLC22A7; solute carrier family 22 (organic anion transporter) member 7; Solute carrier family 22; Solute carrier family 22 member 7

Target Background

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.