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Amino acids 863-1100 form the expressed segment for recombinant Human SORBS2. This SORBS2 protein is expected to have a theoretical molecular weight of 33.1 kDa. The SORBS2 protein was expressed in e.coli. The SORBS2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant SORBS2 protein during the following stages.The human Sorbin and SH3 domain-containing protein 2 (SORBS2) is a multifunctional scaffold protein involved in the regulation of various cellular processes. SORBS2 contains sorbin homology (SoHo) and multiple SH3 domains, enabling interactions with other proteins. It plays a crucial role in the organization of the actin cytoskeleton, cell adhesion, and signal transduction. SORBS2 is implicated in processes such as cell migration, invasion, and response to mechanical stress. Additionally, SORBS2 has been associated with cardiovascular diseases, cancer, and neurological disorders. Research on SORBS2 aims to unravel its intricate roles in different cellular contexts, contributing to a comprehensive understanding of its functions and potential therapeutic applications.
Amino acids 863-1100 form the expressed segment for recombinant Human SORBS2. This SORBS2 protein is expected to have a theoretical molecular weight of 33.1 kDa. The SORBS2 protein was expressed in e.coli. The SORBS2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant SORBS2 protein during the following stages.The human Sorbin and SH3 domain-containing protein 2 (SORBS2) is a multifunctional scaffold protein involved in the regulation of various cellular processes. SORBS2 contains sorbin homology (SoHo) and multiple SH3 domains, enabling interactions with other proteins. It plays a crucial role in the organization of the actin cytoskeleton, cell adhesion, and signal transduction. SORBS2 is implicated in processes such as cell migration, invasion, and response to mechanical stress. Additionally, SORBS2 has been associated with cardiovascular diseases, cancer, and neurological disorders. Research on SORBS2 aims to unravel its intricate roles in different cellular contexts, contributing to a comprehensive understanding of its functions and potential therapeutic applications.
| Cat.No | ACP01525 | Target Name | SORBS2 |
|---|---|---|---|
| Target Synonyms | (Arg-binding protein 2)(ArgBP2)(Arg/Abl-interacting protein 2)(Sorbin) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 863-1100aa |
| Mol Weight | 33.1 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O94875 |
|---|
Uniprot Id
O94875
Target Species
Human
Target Name
SORBS2
Target Full Name
Sorbin and SH3 domain-containing protein 2
Target Function
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
Target Subcellular Location
Cytoplasm, perinuclear region. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium.
Target Tissue Specificity
Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. In the panc
Target Research Area
Signal Transduction
Target Synonyms
Arg binding protein 2; Arg-binding protein 2; Arg/Abl interacting protein 2; Arg/Abl interacting protein; Arg/Abl-interacting protein 2; ArgBP2; KIAA0777; PRO0618; sorbin and SH3 domain containing 2; Sorbin and SH3 domain-containing protein 2; Sorbin; Sorbs2; SRBS2_HUMAN
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