Recombinant Human Sorbin and SH3 domain-containing protein 2 (SORBS2), Truncated

Uniprot Id

O94875

Target Species

Human

Target Name

SORBS2

Target Full Name

Sorbin and SH3 domain-containing protein 2

Target Function

Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.

Target Subcellular Location

Cytoplasm, perinuclear region. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium.

Target Tissue Specificity

Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. In the panc

Target Research Area

Signal Transduction

Target Synonyms

Arg binding protein 2; Arg-binding protein 2; Arg/Abl interacting protein 2; Arg/Abl interacting protein; Arg/Abl-interacting protein 2; ArgBP2; KIAA0777; PRO0618; sorbin and SH3 domain containing 2; Sorbin and SH3 domain-containing protein 2; Sorbin; Sorbs2; SRBS2_HUMAN