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| Cat.No | ACP05896 | Target Name | SPG11 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96JI7 |
|---|
Uniprot Id
Q96JI7
Target Species
Human
Target Name
SPG11
Target Full Name
Spatacsin
Target Function
May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.
Target Involvement
Spastic paraplegia 11, autosomal recessive (SPG11); Amyotrophic lateral sclerosis 5, juvenile (ALS5); Charcot-Marie-Tooth disease 2X (CMT2X)
Target Subcellular Location
Cytoplasm, cytosol. Nucleus. Cell projection, axon. Cell projection, dendrite.
Target Tissue Specificity
Expressed in all structures of brain, with a high expression in cerebellum. Expressed in cortical projection neurons.
Target Synonyms
Colorectal carcinoma associated protein; Colorectal carcinoma-associated protein; DKFZp762B1512; FLJ21439; KIAA1840; Spastic paraplegia 11 (autosomal recessive); Spastic paraplegia 11; Spastic paraplegia 11 protein; Spatacsin; SPG 11; Spg11; SPTCS_HUMAN
Target Background
The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene.
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