Recombinant Human Sperm-associated antigen 6 (SPAG6)

Uniprot Id

O75602

Target Species

Human

Target Name

SPAG6

Target Full Name

Sperm-associated antigen 6

Target Function

Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.

Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme.

Target Tissue Specificity

Highly expressed in testis.

Target Synonyms

axoneme central apparatus protein; DKFZp434I153; MGC26276; PF16; PF16 protein homolog; Protein PF16 homolog; Repro SA 1; Repro-SA-1; SPAG6; SPAG6_HUMAN; Sperm associated antigen 6; Sperm flagellar protein; Sperm-associated antigen 6

Target Background

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.