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| Cat.No | ACP06251 | Target Name | SGPP1 |
|---|---|---|---|
| Target Synonyms | SGPP1; SPP1; Sphingosine-1-phosphate phosphatase 1; SPPase1; Spp1; hSPP1; hSPPase1; EC 3.1.3.-; Sphingosine-1-phosphatase 1; Sphingosine-1-phosphate phosphohydrolase 1; SPP-1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BX95 |
|---|
Uniprot Id
Q9BX95
Target Species
Human
Target Name
SGPP1
Target Full Name
Sphingosine-1-phosphate phosphatase 1
Target Function
Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger. Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle. Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic retiulum to the Golgi apparatus. The modulation of intracellular ceramide levels in turn regulates apoptosis. Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries. Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels. Involved in the regulation of epidermal homeostasis and keratinocyte differentiation
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families
Type 2 lipid phosphate phosphatase family
Target Tissue Specificity
Ubiquitous, with the strongest level in placenta and kidney.
Target Synonyms
SGPP1; SPP1; Sphingosine-1-phosphate phosphatase 1; SPPase1; Spp1; hSPP1; hSPPase1; EC 3.1.3.-; Sphingosine-1-phosphatase 1; Sphingosine-1-phosphate phosphohydrolase 1; SPP-1
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