Recombinant Human Spindlin-1 (SPIN1)

Uniprot Id

Q9Y657

Target Species

Human

Target Name

SPIN1

Target Full Name

Spindlin-1

Target Function

Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Target Subcellular Location

Nucleus. Nucleus, nucleolus.

Target Protein Families

SPIN/STSY family

Target Tissue Specificity

Highly expressed in ovarian cancer tissues.

Target Research Area

Cell Biology

Target Synonyms

OCR; Ovarian cancer-related protein; SPIN; Spin1; SPIN1_HUMAN; Spindlin-1

Target Background

Enables methylated histone binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of transcription, DNA-templated; and rRNA transcription. Located in cytosol and nucleus.