Recombinant Human Splicing factor 3B subunit 1 (SF3B1), Truncated

Uniprot Id

O75533

Target Species

Human

Target Name

SF3B1

Target Full Name

Splicing factor 3B subunit 1

Target Function

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

Target Subcellular Location

Nucleus. Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.

Target Protein Families

SF3B1 family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

Hsh155; OTTHUMP00000205700; OTTHUMP00000205702; OTTHUMP00000225001; OTTHUMP00000225002; Pre mRNA processing 10; Pre mRNA splicing factor SF3b, 155 kDa subunit; Pre-mRNA splicing factor SF3b 155 kDa subunit; Pre-mRNA-splicing factor SF3b 155 kDa subunit; PRP10; PRPF10; SAP 155; SAP155; sf3b1; SF3B1_HUMAN; SF3b155; Spliceosome associated protein 155; Spliceosome-associated protein 155; Splicing factor 3B subunit 1; Splicing factor 3b, subunit 1, 155kDa

Target Background

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.