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The region for expressing recombinant Human STC1 contains amino acids 39-247. The expected molecular weight for the STC1 protein is calculated to be 50.6 kDa. This STC1 protein is produced using e.coli expression system. The STC1 coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant STC1 protein in following stages of expression and purification.Human stanniocalcin-1 (STC1) is known to regulate cellular responses to stress, inflammation, and hypoxia. It has been implicated in angiogenesis, cell proliferation, and apoptosis, indicating its involvement in tissue development and repair. Moreover, STC1 has been associated with cancer, with varying roles in different types of tumors, either promoting or inhibiting tumor progression. In addition to its endocrine functions, STC1 acts as a paracrine or autocrine factor in various tissues. The diverse functions of STC1 make it an intriguing molecule with potential implications in both normal physiology and disease states, particularly in the context of cancer and tissue homeostasis.
The region for expressing recombinant Human STC1 contains amino acids 39-247. The expected molecular weight for the STC1 protein is calculated to be 50.6 kDa. This STC1 protein is produced using e.coli expression system. The STC1 coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant STC1 protein in following stages of expression and purification.Human stanniocalcin-1 (STC1) is known to regulate cellular responses to stress, inflammation, and hypoxia. It has been implicated in angiogenesis, cell proliferation, and apoptosis, indicating its involvement in tissue development and repair. Moreover, STC1 has been associated with cancer, with varying roles in different types of tumors, either promoting or inhibiting tumor progression. In addition to its endocrine functions, STC1 acts as a paracrine or autocrine factor in various tissues. The diverse functions of STC1 make it an intriguing molecule with potential implications in both normal physiology and disease states, particularly in the context of cancer and tissue homeostasis.
| Cat.No | ACP02285 | Target Name | STC1 |
|---|---|---|---|
| Target Synonyms | Stanniocalcin 1; Stanniocalcin; Stanniocalcin-1; STC; STC-1; Stc1; STC1_HUMAN | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 39-247aa |
| Mol Weight | 50.6kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P52823 |
|---|
Uniprot Id
P52823
Target Species
Human
Target Name
STC1
Target Full Name
Stanniocalcin-1
Target Function
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
Target Subcellular Location
Secreted.
Target Protein Families
Stanniocalcin family
Target Tissue Specificity
Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, l
Target Research Area
Metabolism, Signal Transduction
Target Synonyms
Stanniocalcin 1; Stanniocalcin; Stanniocalcin-1; STC; STC-1; Stc1; STC1_HUMAN
Target Background
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.
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