Recombinant Human Sushi repeat-containing protein SRPX2 (SRPX2)

Uniprot Id

O60687

Target Species

Human

Target Name

SRPX2

Target Full Name

Sushi repeat-containing protein SRPX2

Target Function

Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.

Target Involvement

Rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX)

Target Subcellular Location

Secreted. Cytoplasm. Cell surface. Cell junction, synapse.

Target Tissue Specificity

Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed

Target Research Area

Neuroscience

Target Synonyms

BPP; CBPS; PMGX; RESDX; SRPUL; SRPX 2; SRPX2; SRPX2_HUMAN; Sushi repeat containing protein SRPX2; Sushi repeat containing protein X linked 2; Sushi repeat protein; Sushi repeat-containing protein SRPX2

Target Background

This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and cognitive disability.