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This Recombinant Human SMARCB1 protein is an invaluable resource for researchers in the field of cell cycle regulation and related studies. The SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) is a critical component of the SWI/SNF chromatin remodeling complex, which plays a pivotal role in transcriptional regulation, DNA repair, and cell cycle progression. Disruptions in the function of this protein have been implicated in various human cancers and developmental disorders. Our Recombinant Human SMARCB1 protein is produced using a state-of-the-art baculovirus expression system, which ensures proper folding and post-translational modifications, providing a product that closely mimics the native protein. The expression region spans from 2-376aa, capturing the functionally relevant partial sequence of SMARCB1. An N-terminal 6xHis-tag facilitates efficient purification and detection, ensuring a high-quality and consistent product for your research needs. The purity of our Recombinant Human SMARCB1 protein is greater than 90% as determined by SDS-PAGE, confirming the excellent quality of the protein. We offer this product in both liquid and lyophilized powder formats, allowing you to choose the most suitable option for your experimental needs. Trust our Recombinant Human SMARCB1 protein for your cell cycle research and achieve exceptional results.
This Recombinant Human SMARCB1 protein is an invaluable resource for researchers in the field of cell cycle regulation and related studies. The SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) is a critical component of the SWI/SNF chromatin remodeling complex, which plays a pivotal role in transcriptional regulation, DNA repair, and cell cycle progression. Disruptions in the function of this protein have been implicated in various human cancers and developmental disorders.
Our Recombinant Human SMARCB1 protein is produced using a state-of-the-art baculovirus expression system, which ensures proper folding and post-translational modifications, providing a product that closely mimics the native protein. The expression region spans from 2-376aa, capturing the functionally relevant partial sequence of SMARCB1. An N-terminal 6xHis-tag facilitates efficient purification and detection, ensuring a high-quality and consistent product for your research needs.
The purity of our Recombinant Human SMARCB1 protein is greater than 90% as determined by SDS-PAGE, confirming the excellent quality of the protein. We offer this product in both liquid and lyophilized powder formats, allowing you to choose the most suitable option for your experimental needs. Trust our Recombinant Human SMARCB1 protein for your cell cycle research and achieve exceptional results.
| Cat.No | ACP02795 | Target Name | SMARCB1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Baculovirus |
| Expression Range | 2-376aa | Mol Weight | 45.0kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q12824 |
|---|
Uniprot Id
Q12824
Target Species
Human
Target Name
SMARCB1
Target Full Name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Target Function
Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.
Target Involvement
Rhabdoid tumor predisposition syndrome 1 (RTPS1); Schwannomatosis 1 (SWNTS1); Coffin-Siris syndrome 3 (CSS3)
Target Subcellular Location
Nucleus.
Target Protein Families
SNF5 family
Target Research Area
Cancer, Cell Cycle
Target Synonyms
BAF47; BRG1-associated factor 47; hSNF5; INI1; Integrase interactor 1 protein; Malignant rhabdoid tumor suppressor; RDT; RTPS1; Sfh1p; SMARCB1; SNF5 homolog; SNF5_HUMAN; SNF5L1; Snr1; Sucrose nonfermenting yeast homolog like 1; SWI/SNF complex component SNF5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI10; Transcription factor TYE4; Transcription regulatory protein SNF5; TYE4
Target Background
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene.
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