Recombinant Human Synaptonemal complex central element protein 1 (SYCE1)

Uniprot Id

Q8N0S2

Target Species

Human

Target Name

SYCE1

Target Full Name

Synaptonemal complex central element protein 1

Target Function

Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.

Target Involvement

Premature ovarian failure 12 (POF12); Spermatogenic failure, 15 (SPGF15)

Target Subcellular Location

Nucleus. Chromosome.

Target Protein Families

SYCE family

Target Synonyms

SYCE1; C10orf94; Synaptonemal complex central element protein 1; Cancer/testis antigen 76; CT76

Target Background

This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants.